Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients

Nanjing PLA General Hospital

Status: Completed

Conditions: Inflammation; Enteral Nutrition; Critical Illness

Study type: Observational

Funder types: Other

Identifiers

NCT03612206

2016NLYZDRC022

Details and patient eligibility

About

Early enteral nutrition(EEN) is an important treatment for critical ill patients and attenuate systemic inflammation, but the mechanisms are not clear. Thus the investigator conducted this study to observe if EEN affects systemic inflammation though regulation of blood acetylcholine

Enrollment: 113 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• initiating enteral nutrition within the first 24-48h after intensive care unit (ICU) admission
• age more than 18 years
• Acute Physiology and Chronic Health Evaluation II (APACHE II) score >8

Exclusion criteria

• not expected to survive 24 hours
• pregnancy
• any terminal stage disease