Effect of Early Physical Exercise on Pulmonary Ventilation and Recruitment (EFRA)

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Completed

Conditions: Critical Illness

Treatments: Other: C: Walk in place; Other: B: Chair - Arm Cycle ergometer; Other: A: Chair - Leg Cycle ergometer

Study type: Interventional

Funder types: Other

Identifiers

NCT02226406

EIT-Early Exercise

Details and patient eligibility

About

In the critically patient bed rest and immobilization are some of the responsable of the development of respiratory complications. Early physical exercise is a tool to prevent respiratory complications as lost of respiratory muscle strength, decrease in functional residual capacity and hypoxemia improving oxygenation.

New technology as electrical impedance tomography (EIT) are available to visualize changes of regional lung aeration.

The aim of this study is to assess the effect of early physical exercise improving alveolar recruitment and pulmonary ventilation in intensive care unit (ICU) patients, evaluated with EIT.

The ICU patients included at day of evaluation will be evaluated continuously with EIT in different positions. 1) in the supine position (at 30° of inclination), 2) Sitting in chair 3) Active physical exercise 4) And rest in chair after exercise

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient admitted at the Intensive Care Medical/Surgical Unit of Clinic Saint Luc
• Days of hospitalization between 1 and 10
• Hemodynamically stable
• Patient or family member sign the informed consent

Exclusion criteria

• With risk of evisceration
• Therapy withdrawal
• With cardiac devices (Pace Maker)
• Persistent cough
• Patches or open wounds in zone of electrodes
• Presence of high vasopressor medication (noradrenaline > 3 mg/h)
• PEEP > 15 cm H2
• Acute Myocardial Infarction
• Active bleeding
• Intracranial pressure > 20 mm Hg or with major instability

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 3 patient groups

Legs Cycloergometer Group (A)

Experimental group

Description:

Patients randomized in this group will do 10 minutes of legs cycloergometer active exercise. Continuously evaluated with electric impedance tomography.

Treatment:

Other: A: Chair - Leg Cycle ergometer

Hands Cycloergometer Group (B)

Experimental group

Description:

Patients randomized in this group will do 10 minutes of hand cycloergometer active exercise. Continuously evaluated with electric impedance tomography.

Treatment:

Other: B: Chair - Arm Cycle ergometer

Walk in place (C)

Experimental group

Description:

Patients randomized in this group will do 10 minutes of active walk in place. Continuously evaluated with electric impedance tomography.

Treatment:

Other: C: Walk in place