Effect of Electroconvulsive Therapy (ECT) and Transcranial Magnetic Stimulation(TMS) on Brain Derived Neurotrophic Factor (BDNF) in Depressed Patients.

Queen's University

Status: Completed

Conditions: Depression

Study type: Observational

Funder types: Other

Identifiers

NCT00630123

PSIY-252-06

Details and patient eligibility

About

To investigate the change in brain derived neurotrophic factor (BDNF) between pre and post treatment for patients with depression with either ECT or TMS.

Enrollment: 36 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• MDD or bipolar disorder;
• current depressive episode, ham-d17>17 and ymrs<8;
• recommended to receive ECT or TMS as part of clinical care;
• male/female;
• age 18-65;
• inpatient or outpatient;
• comorbid dysthymic disorder, gad, or social anxiety will be included;
• able to give written consent and agree.

Exclusion criteria

• current manic, hypomanic, or mixed episode, ymrs>7;
• current schizophrenia, anorexia, bulimia, substance dependence (current within past 6 months excluding caffeine and nicotine);
• TMS or ECT in the last 3 months;
• any other primary diagnosis;
• uncontrolled medical illness;
• epilepsy or severe personality disorder at the discretion of the investigators;
• 3 weeks prior to first blood test, antidepressants, mood stabilizers, antipsychotics can not be added or increased;
• pregnant women or women of childbearing potential not willing to use appropriate contraception, nursing women;
• known intolerance or lack of response to treatment receiving as judged by the investigator;
• medical conditions that would affect serum levels of BDNF;
• involvement in planning and conduct of the study.

Trial design

36 participants in 2 patient groups

1

Description:

Electroconvulsive Therapy (ECT): blood sample taken from this group at start and after therapy; subjects not randomized to therapy option.

2

Description:

Transcranial Magnetic Stimulation (TMS): blood sample taken from this group at start and after therapy; subjects not randomized to therapy option.