Effect of Electronic Cigarette Use on Cough Reflex Sensitivity

Montefiore Medicine Academic Health System

Status and phase: Completed; Phase 4

Conditions: Cough

Treatments: Device: electronic cigarette exposure

Study type: Interventional

Funder types: Other

Identifiers

NCT02203162

2014-3288

Details and patient eligibility

About

Although electronic cigarettes (e-cigs) are now widely used, very little information exists regarding the effect of electronic cigarette use (vaping) on the respiratory system. The aim of this study is to evaluate the acute effect of one e-cig vaping session (30 puffs 30 seconds apart) on cough reflex sensitivity in healthy adult nonsmokers.

Full description

30 adult nonsmokers will have their cough reflex sensitivity measured at baseline, 15 minutes after an e-cig vaping session, and 24 hours subsequently. One e-cig vaping session will consist of 30 puffs of an e-cg (Blu) 30 seconds apart, which will deliver the approximate nicotine amount delivered by one tobacco cigarette. Cough reflex sensitivity, defined as C5, the concentration of capsaicin inducing 5 or more coughs, is the standard end point of cough challenge studies.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adults (age18 years and above)
• nonsmokers

Exclusion criteria

• previous smoker
• asthma/other respiratory illness
• acute viral upper respiratory tract infection (common cold) in previous 4 weeks

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

cough reflex sensitivity

Experimental group

Description:

electronic cigarette exposure

Treatment:

Device: electronic cigarette exposure