Effect of Electrostimulation in Chronic Obstructive Pulmonary Disease (COPD) (ExaEMS2005)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Device: Sham stimulation; Device: Electrostimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01167283

APARD

Details and patient eligibility

About

This study was designed to test the following hypothesis:

To investigate whether COPD muscles can respond to stimuli in terms of changes in fiber-type distribution.

Full description

Background: Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD). It is characterized by muscle fiber-type redistribution and oxidative stress. Classical training does not improve these features.

Objectives: To investigate whether electrostimulation program following exacerbation can modify muscle structure and function in COPD patients.

Method: We propose to conduct a controlled and randomized clinical trial comparing the efficacy of muscle electrostimulation training of the lower limbs to sham training in 15 patients with COPD. Patients are included in either 6 weeks of electrostimulation training (active treatment group) or 6 weeks of sham electrostimulation. Primary outcomes were changes in muscle structure, muscle oxidative stress and their relationship with quadriceps force and exercise tolerance.

Enrollment: 15 patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD patients during or after exacerbation

Exclusion criteria

• Comorbidities that could limit exercise training
• Obesity (body mass index [BMI] > 30 kg/m²)
• Neuromuscular disease
• Pacemaker implantation

Trial design

15 participants in 2 patient groups

Electrostimulation

Active Comparator group

Description:

Neuromuscular electrical stimulation

Treatment:

Device: Electrostimulation

Sham stimulation

Sham Comparator group

Description:

Sham stimulation

Treatment:

Device: Sham stimulation