Effect of Eliminating Gastric Residual Volume Monitoring on Ventilator Associated Events

Damanhour University

Status: Not yet enrolling

Conditions: Ventilator Associated Pneumonia

Treatments: Procedure: eliminating gastric residual volume monitoring

Study type: Interventional

Funder types: Other

Identifiers

NCT06059040

elimination GRV monitor on VAE

Details and patient eligibility

About

The aims of this study are to investigate the effect of eliminating routine GRV monitoring on VAEs in patients receiving MV and early EF, Determine the effect of eliminating routine GRV monitoring on nutritional adequacy in patients receiving MV and early EF and evaluate the effect of eliminating routine GRV monitoring on feeding intolerance in patients receiving enteral feeding.

Full description

Early enteral nutrition (EN) is consistently recommended as first line nutrition therapy in critically ill patients since it favorably alters outcome, providing both nutrition and non-nutrition benefits. However, critically ill patients receiving mechanical ventilation (MV) are at risk for regurgitation, pulmonary aspiration, and eventually ventilator-associated pneumonia (VAP). EN may increase these risks when gastrointestinal (GI) dysfunction is present. Gastric residual volume (GRV) is considered a surrogate parameter of GI dysfunction during the progression of enteral feeding in the early phase of critical illness and beyond. About 62% of critically ill patients receive enteral nutrition (EN) and in patients on MV, enteral feeding was connected to a threefold increase in the development of VAP.

A new surveillance definition of ventilator-associated events (VAE) was introduced by the National Healthcare Safety Network (NHSN) in 2013 to identify patients who develop complications of MV. It outlines the various events in a step-by-step fashion, beginning with ventilator-associated complications (VAC), moving on to infectious complications (IVAC), and finally VAP. According to the NHSN, VAEs occur within 9% to 40% of mechanically ventilated patients

Enrollment: 160 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults (aged≥18 years)
• Newly admitted mechanically ventilated patients who are attached to a mechanical ventilator for at least 48 hours.
• Starting enteral nutrition via a nasogastric tube within 36 hours after intubation.

Exclusion criteria

• Abdominal surgery within the past month.
• History of esophageal, duodenal, pancreatic, or gastric surgery.
• Bleeding from the esophagus, stomach, or bowel.
• Enteral nutrition via a jejunostomy or gastrostomy.
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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160 participants in 2 patient groups

intervention groups

Active Comparator group

Description:

Patients in the intervention group will not be monitored for GRV (no GRV monitoring) and will be evaluated for the presence of feeding intolerance indicators such as vomiting, regurgitation, and abdominal distention.

Treatment:

Procedure: eliminating gastric residual volume monitoring

control group

No Intervention group

Description:

Patients in the control group will be subjected to GRV monitoring (with GRV monitoring).