Inclusion Criteria:
- Age≥18 years and less than 75 years
- Essential hypertension patients
- Sedentary systolic blood pressure≥140mmHg and less than 180mmHg, and/or sedentary diastolic blood pressure≥90mmHg and less than 110mmHg
- Reproductive women agree to take a reliable contraception measure during the trial
- Written informed consent
Exclusion Criteria:
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Pregnant women
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Women within lactateion period
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Hypersensitive to Angiotensin-Converting Enzyme Inhibitor (ACEI) or folic acid
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Easily hypersensitiveness
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Diagnosed secondum hypertension or skeptical secondum hypertension
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Severe hypertension (sedentary systolic blood pressure greater than or equal to 180 mmHg and/or sedentary diastoleic blood pressure greater than or equal to 110 mmHg)
-
Severe diseases:
- Cardiovascular system
- Diagnosed cardia insufficiency (New York Health Association [NYHA] III level and higher)
- Hypertrophic obstructive cardiomyopathy (HOCM)
- Clinical significantly Valvular Disease of the Heart (VDH)
- Acute coronary syndrome or coronary artery interventional therapy or coronary artery bypass graft within three months
- Severe arrhythmia such as atrial flutter, atrial fibrillation, ventricular arrhythmia above Lown ?, atrioventricular block above II level, etc.
- Alimentary system disorders
- Active virus hepatitis
- Any of alanine aminotransferase (ALT), aspartate aminotransferase (AST), galactosylhydroxylysyl glucosyltransferase (GGT), alkaline phosphatase (ALP), total bilirubin (TBIL), Direct Bilirubin (DB) was above 2 times of it's normal value upper limit, albumin (ALB) greater than 30 g/L
- Stomach bulk resect and gastrojejunostomy, stomach intestine malabsorption
Urinary system:
- Serum creatinine greater than or equal to 200 mmol/L
- Diagnosed stenosis of renal artery, solitary kidney
- Renal transplantation
Endocrine system:
- Type 1 diabetes mellitus or uncontrolled type 2 diabetes mellitus (fasting glucose greater than or equal to 11.1 mmol/L)
- Diagnosed and uncontrolled hyperthyrosis
Respiratory system:
- Chronic cough nervous or psyche system:
- Transient Ischemia Attach (TIA) or stoke within 3 months
- Severe peripheral nerve or vegetative nerve functional disturbance
- Psyche or nervous system dysfunction
- Drugs or alcohol dependence
Others:
- Malignant tumor
- Malnutrition, haematogenesis dysfunction, etc.
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Taking other antihypertensive drugs
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Taking folic acid or other Vitamin B groups
Primary Outcome Measures:
- Blood pressure of study participants was measured at baseline, 2th week, 4th week, 6th week and at the end of trial
- Subjects' plasma total homocysteine concentration were measured at baseline, 4th week and at 8th week.
Secondary Outcome Measures:
- Participants' living habit and life style were collected at baseline with the original questionnaires.
- A follow up questionnaire was sent out at 2th week, 4th week, 6th week and at the end of the trial.