Effect of Endometrial Scratching on Assisted Reproduction Outcomes: a Randomized Controlled Trial

University of Sao Paulo

Status: Terminated

Conditions: Subfertility

Treatments: Procedure: Endometrial Scratching

Study type: Interventional

Funder types: Other

Identifiers

NCT02180256

CAAE: 30504514.6.0000.5440

Details and patient eligibility

About

To examine whether endometrial scratching (or injury) using a Pipelle endometrial sampler, performed on the first seven days of the menstrual cycle, is able to improve pregnancy rates in women who will be submitted to a fresh embryo transfer.

Enrollment: 107 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• First four days of the menstrual cycle, just before starting controlled ovarian stimulation for planned IVF and fresh embryo transfer.
• Not have performed endometrial scratching in the last 90 days.

Exclusion criteria

• None

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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107 participants in 4 patient groups

Endoscratching, non-RIF

Experimental group

Description:

Endometrial scratching. Women with no more than 1 previous unsuccessful embryo transfer. Pipelle in the first seven days of the menstrual cycle, just before starting controlled ovarian stimulation.

Treatment:

Procedure: Endometrial Scratching

Control, non-RIF

No Intervention group

Description:

No intervention. Women with no more than 1 previous unsuccessful embryo transfer.

Endoscratching, RIF

Experimental group

Description:

Endometrial scratching. Women with 2 or more previous unsuccessful embryo transfers. Pipelle in the first seven days of the menstrual cycle, just before starting controlled ovarian stimulation.

Treatment:

Procedure: Endometrial Scratching

Control, RIF

No Intervention group

Description:

No intervention. Women with 2 or more previous unsuccessful embryo transfers.