Effect of Endometrial Thickness on IVF Outcome

Zhengzhou University

Status: Unknown

Conditions: Infertility

Treatments: Procedure: Embryo transfer

Study type: Observational

Funder types: Other

Identifiers

NCT02420704

RMCZZU-Endometrial thickness

Details and patient eligibility

About

Although many studies have evaluated the relationship between endometrial thickness and IVF outcome, the results are still controversial. We notice that, during our daily work, for patients undergoing cleavage stage embryo transfer, endometrial thickness seems to have a huge impact on IVF outcome; however, for blastocyst stage embryo transfers, IVF outcome seems to have little association with endometrial thickness. Thus, the aim of this prospective observational study is to explore the relationship between endometrial thickness and IVF outcome in patients undergoing cleavage stage and blastocyst stage embryo transfers, respectively.

Enrollment: 500 estimated patients

Sex: Female

Ages: 22 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between 22-38 years old;
• the first cycle of IVF treatment with standard long protocol;
• transfrred with at least two high quality cleavage stage embryos, or with at least one high quality blastocyst stage embryo.

Exclusion criteria

• PGD cycles;
• gamete donation cycles

Trial design

500 participants in 6 patient groups

Cleavage stage-thin endometrial

Description:

Patients transferred with cleavage stage embryo, with endometrial thickness ≤7mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.

Treatment:

Procedure: Embryo transfer

Cleavage stage-medium endometrial

Description:

Patients transferred with cleavage stage embryo, with endometrial thickness 8-13mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.

Treatment:

Procedure: Embryo transfer

Cleavage stage-thick endometrial

Description:

Patients transferred with cleavage stage embryo, with endometrial thickness ≥14mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.

Treatment:

Procedure: Embryo transfer

Blastocyst stage-thin endometrial

Description:

Patients transferred with blastocyst stage embryo, with endometrial thickness ≤7mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.

Treatment:

Procedure: Embryo transfer

Blastocyst stage-medium endometrial

Description:

Patients transferred with blastocyst stage embryo, with endometrial thickness 8-13mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.

Treatment:

Procedure: Embryo transfer

Blastocyst stage-thick endometrial

Description:

Patients transferred with blastocyst stage embryo, with endometrial thickness ≥14mm on the day of HCG (human chorionic gonadotropin) administration for fresh cycles, or on the day starting to use progesterone for frozen thawed cycles.

Treatment:

Procedure: Embryo transfer