Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners

Gdansk University of Physical Education and Sport

Status and phase: Enrolling; Phase 4

Conditions: Health Knowledge, Attitudes, Practice

Treatments: Dietary Supplement: Placebo supplementation; Dietary Supplement: CoQ10 supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT06619249

AWFiS/2024_3_ZJ

Details and patient eligibility

About

The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.

Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?

Participants will:

Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep their food and training diary.

Enrollment: 24 estimated patients

Sex: Male

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• training experienced for minimum 2 years
• running training at least 2 times per week
• Personal Best on 10k (<50 minutes)

Exclusion criteria

• taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
• injured in last 6 months to avoid n number reduction

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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24 participants in 2 patient groups, including a placebo group

CoQ10-treated participants

Experimental group

Description:

The participants will be treated with CoQ10 supplements

Treatment:

Dietary Supplement: CoQ10 supplementation

Placebo-treated participants

Placebo Comparator group

Description:

The participants will be treated with placebo

Treatment:

Dietary Supplement: Placebo supplementation