Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Status: Completed

Conditions: Pancreatitis

Treatments: Other: No enzyme therapy; Drug: Creon

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01154608

PANCREATITE

Details and patient eligibility

About

Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic pancreatitis
• Pancreatic insufficiency
• Enzyme therapy treatment

Exclusion criteria

• Hepatic failure
• Pregnancy
• Positive serology to HIV, HCV, AGHbS, gastro-intestinal disease

Trial design

11 participants in 2 patient groups, including a placebo group

pancreatic enzymes

Experimental group

Treatment:

Drug: Creon

control

Placebo Comparator group

Treatment:

Other: No enzyme therapy