Effect of Epidural Dexamethasone on Labor Analgesia

Kasr El Aini Hospital

Status and phase: Unknown; Phase 2

Conditions: Labor

Treatments: Drug: Dexamethasone and levobupivacaine; Drug: Levobupivacaine and Dexamethasone; Drug: Levobupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02665936

wahdan

Details and patient eligibility

About

The purpose of this study is to detect whether the addition of epidural dexamethasone will prolong labor analgesia.

Enrollment: 90 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status I, II
• normal vaginal delivery In early active phase of labor
• singleton cephalic presentation at term

Exclusion criteria

• complicated pregnancies
• morbid obesity
• diagnosed fetal abnormalities
• contra-indications to regional anesthesia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups

group L

Active Comparator group

Description:

Epidural levobupivacaine 0.125% (Chirocaine) in normal saline in a total volume of 10 ml will be administered epidurally in active stage of labor

Treatment:

Drug: Levobupivacaine

group LD4

Active Comparator group

Description:

Epidural levobupivacaine 0.125%(Chirocaine) in normal saline combined with dexamethasone 4 mg in a total volume 10 ml

Treatment:

Drug: Dexamethasone and levobupivacaine

group LD8

Active Comparator group

Description:

Epidural levobupivacaine 0.125%(Chirocaine) in normal saline combined with dexamethasone 8 mg in a total volume 10 ml

Treatment:

Drug: Levobupivacaine and Dexamethasone