Effect of Epinephrine on Post-polypectomy Pain

Indiana University

Status and phase: Completed; Phase 4

Conditions: Colonic Polyp

Treatments: Drug: Epinephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT04065451

1908473351

Details and patient eligibility

About

Epinephrine is widely used in endoscopic mucosal resection of large polyps to prevent post-polypectomy bleeding. No previous studies looked at increase in immediate post-polypectomy pain with the use of epinephrine.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

1. Patients aged 18 years and over
2. Patients scheduled for treatment of large (≥ 20 mm) colorectal polyps
3. Able to sign informed consent

Exclusion Criteria

1. Patients previously enrolled in the study
2. Pedunculated polyps
3. Polyps not amenable to endoscopic resection
4. Patients allergic or sensitive to epinephrine
5. Patients with coronary artery disease who have had a myocardial infarction in the past year, or had coronary stenting in the past year, or had angina in the past year.
6. Patients electing anesthesia other than monitored anesthesia care with propofol (MAC) for colonoscopy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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22 participants in 2 patient groups

Epinephrine

Experimental group

Description:

Epinephrine in the submucosal injection fluid (1:200,000)

Treatment:

Drug: Epinephrine

No epinephrine

No Intervention group

Description:

Submucosal injection fluid without epinephrine