Effect of Epinephrine on Systemic Absorption of Mepivacaine in Uremic Patients

Rigshospitalet

Status: Terminated

Conditions: Renal Insufficiency, Chronic

Treatments: Drug: Mepivacaine with epinephrine; Drug: Plain mepivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT01533545

H-3-2011-154

2012-000948-98 (EudraCT Number)

Details and patient eligibility

About

The aim of this study is to determine the effect of epinephrine on systemic absorption of local anaesthetic mepivacaine administered for brachial plexus block in uremic patients scheduled for creation or repair of an arteriovenous fistula. Furthermore, an impact of epinephrine on the central circulation and peripheral tissue oxygenation will be evaluated.

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient acceptance of regional anaesthesia

Exclusion criteria

• peripheral arteriosclerosis
• diabetes mellitus
• bleeding disorder
• infection at the puncture site
• allergy to mepivacaine
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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16 participants in 2 patient groups

Plain mepivacaine

Active Comparator group

Treatment:

Drug: Plain mepivacaine

Mepivacaine with epinephrine

Active Comparator group

Treatment:

Drug: Mepivacaine with epinephrine