Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation

Seoul National University

Status: Completed

Conditions: Hypotension After Reperfusion in Liver Transplantation

Treatments: Drug: placebo control; Drug: epinephrine; Drug: phenylephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT01080625

CWJung_phen_epi_liver TPL

Details and patient eligibility

About

Postreperfusion syndrome (PRS) is a relatively common phenomenon in patients undergoing liver transplantation which is characterized by an acute drop in blood pressure immediately after the prefusion is restored to the transplanted liver. We hypothesized that PRS would be prevented when phenylephrine or epinephrine is administered immediately prior to reperfusion in liver transplantation.

Enrollment: 96 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adults scheduled to undergo liver transplantation

Exclusion criteria

• pediatric liver transplantation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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96 participants in 3 patient groups, including a placebo group

phenylephrine

Experimental group

Description:

100 mcg of phenylephrine is administered at the time of reperfusion

Treatment:

Drug: phenylephrine

epinephrine

Experimental group

Description:

10 mcg of epinephrine is administered iv at the time of reperfusion

Treatment:

Drug: epinephrine

control

Placebo Comparator group

Description:

10 ml of normal saline is administered at the time of reperfusion

Treatment:

Drug: placebo control