Effect of Equivalent Dose of Alfentanil and Sufentanil in Bronchoscopic Treatment (EOEDSAAIBT)

Tongji Hospital

Status: Completed

Conditions: Effect of Drug

Treatments: Drug: Alfentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT06414018

EEDSA

Details and patient eligibility

About

The equivalent dose of sufentanil and afentanil combined with laryngeal mask was used for complex bronchoscopy to observe the intraoperative effect and the influence on the recovery of patients

Full description

Afentanil is a powerful, fast-acting narcotic analgesic, which can effectively inhibit intubation reflex. Compared with sufentanil, it has a short half-life and is safer, and can be used as the first choice for short surgical analgesics. In this study, by comparing the use of equivalent dose sufentanil and afentanil combined with laryngeal mask for complex bronchoscopy, the intraoperative analgesic effect and the influence on the recovery of patients were observed, and a better anesthesia scheme was provided for tracheoscopy.

Enrollment: 80 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-80,
• ASA I-III level;
• BMI 18.5~23.9;

Exclusion criteria

• Patients with full stomach and high risk of reflux aspiration;
• Allergic to benzodiazepines, opioids, rocuronium bromide;
• Those who have taken sedative, analgesic or antidepressant drugs within 24 hours;
• Pregnant and lactating women;
• severe liver and kidney dysfunction;
• Patients with severe anemia and hypoproteinemia;
• Previous drug use history;
• Recently participated in other clinical studies;
• Patients who cannot cooperate with communication.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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80 participants in 2 patient groups

Sufentanil group

Experimental group

Description:

The dose of sufentanil group is 0.2μg/kg

Treatment:

Drug: Alfentanil

Alfentanil

Experimental group

Description:

The dose of aifentanil group is 10μg/kg

Treatment:

Drug: Alfentanil