Effect of Es-ketamine on Postoperative Delirium Among Old Patients With Lobectomy

Zhongnan Hospital

Status: Unknown

Conditions: Postoperative Delirium

Treatments: Procedure: lobectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT04969523

S001

Details and patient eligibility

About

The purpose of this study is the efficiency of es-ketamine on postoperative delirium among old patients with elective lobectomy

Full description

This study aimed to investigate the effect of IV es-ketamine vs saline on the incidence of postoperative delirium. It was hypothesized that IV es-ketamine would reduce the incidence of in-hospital delirium during cardiac surgery lobectomy

Enrollment: 500 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 60 years old; There is no limit on the gender, ASA (American Society of Anesthesiologists )Ⅰ-Ⅲ

Exclusion criteria

• Emergency surgery, severe hepatic and renal dysfunction, shock or coma, psychiatric disease or central nervous system disorder or a history of long-term use of psychiatric medications, cognitive dysfunction, severe arrhythmia or bradycardia, ketamine allergy,drug abuse history and used other sedatives for nearly a week

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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500 participants in 2 patient groups, including a placebo group

es-ketamine

Experimental group

Description:

es-ketamine 0.5mg/kg iv

Treatment:

Procedure: lobectomy

saline

Placebo Comparator group

Description:

iv saline with the same volume of es-ketamine

Treatment:

Procedure: lobectomy