Effect of Exercise, Endocannabinoids and Ketones on Cerebral Metabolism in a Cognitive Disorders Population (PARKA)

Université de Sherbrooke

Status: Active, not recruiting

Conditions: Alzheimer Disease; Parkinson Disease

Treatments: Dietary Supplement: Betaquik MCT supplement

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT04322461

2020-3436

Details and patient eligibility

About

A two months intervention in which two groups of cognitive disorders, Parkinson and Alzheimer's disease, will receive 50g/day of a commercial MCT supplement combined with supervised aerobic exercise 3 times/week. Cognition and ketones will be assess before and after the intervention, along with endocannabinoids plasma concentrations.

Enrollment: 14 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Alzheimer's or parkinson disease diagnostic
• Stable medication associated with the disease
• Able to consent
• Presence of an accompanying person for the first and last visit.
• Ability to read and talk in French

Exclusion criteria

• MMSE < 20
• MCT or coconut oil supplementation
• Coconut allergy
• Cannabis, THC or CBD consumption
• Excessive alcohol consumption
• Physical activity 3x/week
• Presence of an metallic object in the body
• Impossibility to lay in dorsal decubitus for 40 minutes
• Cardiac disease
• Any uncontrolled disease that could interfer with the project.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

14 participants in 2 patient groups

Parkinson disease

Experimental group

Description:

2 months intervention with 50g/day of a commercial MCT supplement combine with supervised aerobic exercise 3x/week.

Treatment:

Dietary Supplement: Betaquik MCT supplement

Alzheimer's disease

Experimental group

Description:

2 months intervention with 50g/day of a commercial MCT supplement combine with supervised aerobic exercise 3x/week.

Treatment:

Dietary Supplement: Betaquik MCT supplement