Effect of Exercise on Cardiometabolic Risk Factors in Type II Diabetic Patients

Cairo University (CU)

Status: Completed

Conditions: Diabetes Mellitus, Type 2

Treatments: Behavioral: High-intensity interval training; Behavioral: Moderate intensity interval training

Study type: Interventional

Funder types: Other

Identifiers

NCT04759469

HIIT on DM

Details and patient eligibility

About

Background: Physical activity is known to modify some of the diabetes risk factors; however, solid evidence is still needed to precisely know the optimum form of training best fits the individual needs of type II diabetic (T2D) patients.

Full description

Objectives: the purpose of this study was to compare between high intensity interval training (HIIT) and moderate-intensity interval training (MIIT) effect on functional capacity (as a cardiorespiratory parameter), and on glucose control and glycated hemoglobin (HbA1C) (as metabolic parameters) in T2D patients, and to test exercise acceptability within these patients. Methods: 60 participants had participated in this study. Their ages ranged from 45 to 65 years. They were randomized into two equal groups (30/group); group (A) did HIIT and group (B) did MIIT. Both groups received 12 weeks of training. Measurements for six minute walking distance (6MWD), fasting blood glucose (FBG), and HbA1C levels were done before and after the study. Physical activity enjoyment scale (PACES) were filled by the patients by the end of the study; testing exercise enjoyment.

Enrollment: 60 patients

Sex: All

Ages: 45 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Controlled type 2 diabetic patients who were clinically stable for at least 3 months before entering the study,
• Aged 45-65 years
• Non-smokers
• body mass index (BMI) ranged between 20 to 39.9 Kg/m2
• Fasting blood glucose ranged from (126-160) mg/dl
• Sedentary lifestyle who didn't engage in physical activity for more than half an hour/ day for at least one month before entering the study.

Exclusion criteria

• unstable medical condition
• smoker, recent surgery
• Body mass index is more than 39.9 kg/m2 or less than 20 kg/m2
• Any known musculoskeletal or neurological conditions that might interfere with the execution or the assessment of the exercise

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

High-intensity interval training (HIIT)

Experimental group

Description:

A high-intensity interval training program for 3 days/week (day after day) for 12 weeks on atreadmill (Biodex RTM500, Biodex Inc., New York), with a gradual increase in the program intensity.

Treatment:

Behavioral: High-intensity interval training

Moderate intensity interval training (MIIT)

Active Comparator group

Description:

A moderate intensity interval training program for 3 days/week (alternate days) on a treadmill (Biodex RTM500, Biodex Inc., New York), with a gradual increase in the program.

Treatment:

Behavioral: Moderate intensity interval training