Effect of Exercise on Disease Activity and Cardiovascular Risk Factors in Patients With Ankylosing Spondylitis

Diakonhjemmet Hospital

Status

Completed

Conditions

Ankylosing Spondyliti

Treatments

Behavioral: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT01436942

Diakonhjemmet Hospital

Details and patient eligibility

About

Background:

Exercise is recommended as a cornerstone in the treatment of ankylosing spondylitis together with medication. Last years, increased risk of cardiovascular diseases in patient with inflammatory diseases is reported, probably caused by inflammation and increased prevalence of traditional risk factors. In both healthy adults and other patient groups, cardiorespiratory and muscular strength exercises have been shown to have a positive effect on inflammation as well as on cardiovascular risk factors. To our knowledge this has not been shown in patients with ankylosing spondylitis.

Objective: The aim of this study is to investigate the effects of a cardiorespiratory and muscular strength exercise program on disease activity and cardiovascular risk factors in patients with ankylosing spondylitis

Enrollment

34 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of ankylosing spondylitis, confirmed by a rheumatologist
Age, 18-70 years
Not using TNF-α medication or steady medication for ≥3 months
Disease activity ≥2.1 on ankylosing spondylitis disease activity score defined as high disease activity
Not participated in a structured cardiorespiratory or muscle strengthening exercise program during the last year (>60 min once per week), including large amounts of brisk walking (>120 min per week)

Exclusion criteria