Effect of Exercise on GDF-15 Levels in Prediabetic Patients

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Status: Enrolling

Conditions: PreDiabetes

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT04799938

ACTİVE GD-15

Details and patient eligibility

About

The aim of this study is to evaluate whether there is a change in GDF-15 levels in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program with guide-based exercise programs.

Full description

GDF-15, which has anorexigenic effects, increases with exercise. In prediabetic patients, GDF-15 is higher than healthy controls. The effect of exercise on GDF-15 levels in prediabetic patients is unknown.

The aim of this study is to evaluate whether there is a change in GDF-15 levels after the application of guideline-based exercise programs in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program.

Enrollment: 70 estimated patients

Sex: Female

Ages: 30 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Body mass index 30-34.9 kg / m2
• Sedentary life-style (Physical activity below 300 kcal / day will be assessed by Minnesota Leisure Physical Activity Questionnaire)
• Those who have sufficient motivation to participate in the exercise program (will be evaluated by face-to-face interview by the researchers)
• Having the same weight for 6 months before participating in the study (± 2.5 kg)
• Those diagnosed with prediabetes by oral glucose tolerance test and / or HbA1c measurement will be included.

Exclusion criteria

• Serious medical condition (e.g. advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.)
• Having cardiovascular disease
• Having diabetes
• Using metformin
• Taking hormone replacement therapy
• less than 1 year life expectancy
• HIV positivity
• Substance use
• Functional dependence
• Cognitive weakness
• Those with other diseases that will affect the study result (respiratory diseases, muscle diseases, etc.)
• Those who use drugs or supplements that will affect the results of the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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70 participants in 3 patient groups

İntevention group

Active Comparator group

Description:

Prediabetic patients with age 30-50 and overweight Standart recommendations Exercise intervention will be made.

Treatment:

Behavioral: Exercise

Control group

No Intervention group

Description:

Prediabetic patients with age 30-50 and overweight Only Standart recommendations

Metformin Group

No Intervention group

Description:

Prediabetic patients who received metformin Standart recommendations