Effect of Exercise on MiR-126 in Individuals With Prediabetes (EMiR-126-PD)

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Status: Completed

Conditions: Prediabetes; microRNA; Exercise

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06809257

EMiR-126-PD

Saglik Bilimleri University

Details and patient eligibility

About

This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes.

Full description

This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes. The hypothesis of our study is that regular aerobic exercise will increase miR-126 expression. Determining the effect of exercise on miR-126 in individuals with prediabetes will contribute to the elucidation of the pathways through which exercise is effective in prediabetes via epigenetic mechanisms.

Enrollment: 64 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals who were newly diagnosed with prediabetes according to the Oral Glucose Tolerance Test (OGTT) and/or HbA1C criteria
• between the ages of 18-60
• were physically inactive (Level 1 according to the International Physical Activity Questionnaire)
• were motivated to exercise
• Individuals who had no obstacle to exercise as a result of the evaluation made by a cardiologist (ECG, exercise ECG test, etc.)
• and who did not show a change in body weight of more than ±2.5 kg in the last six months were included in the study.

Exclusion criteria

• presence of serious medical conditions (e.g. advanced cancer, major neurological or endocrine disorders, respiratory failure)
• current cardiovascular disease, BMI <19 kg/m²
• history of metformin use within the last 6 months
• receiving hormone replacement therapy
• life expectancy less than one year
• HIV positivity
• substance use
• or orthopedic and cognitive disorders that may prevent exercise

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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64 participants in 2 patient groups

Exercise

Active Comparator group

Description:

Individuals in the intervention group were included in a planned aerobic exercise program for 12 weeks.This program was carried out under the supervision of specialist doctors, with the help of sports trainers and physiotherapists, and participants were given 60 minutes of moderate-intensity (50-70% of their maximum heart rate) aerobic exercise three days a week.

Treatment:

Behavioral: Exercise

Control

No Intervention group

Description:

No intervention