Effect of Exercise on Muscle Proteome Signature

Morten Hostrup, PhD

Status: Completed

Conditions: Healthy

Treatments: Other: exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT03270475

ACE

Details and patient eligibility

About

The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

Full description

Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.

Enrollment: 8 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)
• Body mass index (BMI) of 19-26 kg/m2
• Normal ECG (electrocardiography)

Exclusion criteria

• Serious adverse effects to exercise
• Chronic disease

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

Exercise

Experimental group

Description:

12-15 training sessions of 30 min over 4-5 weeks

Treatment:

Other: exercise training