Effect of Exercise Training in Alzheimer's Patients (ExCiTE-A)

University of Genova

Status: Completed

Conditions: Alzheimer Disease

Treatments: Other: Physical training

Study type: Interventional

Funder types: Other

Identifiers

NCT03981159

ExCiTE-A-17-0020

Details and patient eligibility

About

The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.

Full description

Alzheimer's disease is a neurodegenerative disease characterized by progressive and irreversible degeneration of nerve cells. The loss of these cells leads to the continuous decline in muscle function with alterations in biochemical and haematological parameters. The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.

Enrollment: 20 patients

Sex: All

Ages: 80 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects with official diagnosis of Alzheimer's disease;
• Subjects with MMSE higher than12.

Exclusion criteria

• Subjects with MMSE below 12 (indicating severe dementia and impairment).

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

Active group (under physical training)

Experimental group

Description:

Subjects belonging to this arm underwent physical training for three months, twice per week (60 minutes per session).

Treatment:

Other: Physical training

Passive group (no physical training)

No Intervention group

Description:

Subjects served as controls.