Effect of Exercise Training in Lung Cancer

Riphah International University

Status: Completed

Conditions: Lung Cancer, Nonsmall Cell

Treatments: Other: Aerobic training; Other: Pulmonary Exercises

Study type: Interventional

Funder types: Other

Identifiers

NCT05158530

REC/01093 Muheebur Rehman

Details and patient eligibility

About

To determine the effects of exercise training in patients with lung cancer during chemotherapy treatment. In currently accessible literature, majority studies, met-analysis, and systemic reviews are related to surgical procedures and post-op pulmonary Rehabilitation of patients with Lung cancer. In literature, Gap related to the control group was observed also. The current study aimed to fulfill this gap by planning a structured intervention plan for the control group as well. It will also add in literature the deficiency of oncology rehab for patients receiving chemotherapy only.

Full description

Literature suggested that a pulmonary rehabilitation program for patients with non-small cell lung cancer undergoing induction chemo-radiotherapy seems to improve respiratory function. It is particularly recommended for smokers and patients with respiratory impairment.

Enrollment: 40 patients

Sex: All

Ages: 20 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed patients of stage 1 and 2 Non-small cell lung carcinoma (NSCLC) including Adenocarcinoma & squamous cell carcinoma The diagnosis was established within 6 wk prior to enrollment and was confirmed by histology.

Participants are undergoing lung cancer chemotherapy Participant has the willingness to participate in training WHO physical fitness scores 0-1 Able to perform 6-minute walk test (6MWT) at baseline

Exclusion criteria

• • Participant with history of trauma and surgery

  • Patients with lung disease other than lung cancer
  • Uncontrolled hypertension or unstable coronary artery disease.
  • Severe OA, bone or CNS metastases.
  • hemoglobin <10 g/dL
  • Lower than 3,500 white blood cells per microliter of blood

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

40 participants in 2 patient groups, including a placebo group

Interventional Group

Experimental group

Description:

Pulmonary exercises + Aerobic training, 40%-60% intensity 3 days/ week for 4 weeks

Treatment:

Other: Aerobic training

Control group

Placebo Comparator group

Description:

Pulmonary exercises, 3 sessions per week and 3-5 repetitions in a session for 4 weeks.

Treatment:

Other: Pulmonary Exercises