Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients

National Taiwan University

Status: Completed

Conditions: Non-small-cell Lung Cancer

Treatments: Other: Usual care; Behavioral: Exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT01136083

201003064R

Details and patient eligibility

About

Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on

1. circulating VEGF-A
2. muscle growth and function
3. Myostatin

Enrollment: 60 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 40-75 years
• Advanced NSCLC
• Eastern Cooperative Oncology Group performance status of 0 or 1
• Targeted therapy for at least 8 weeks
• Stable condition

Exclusion criteria

• Severe metastasis, cardiopulmonary or musculoskeletal conditions may affect participation in exercise
• Do not understand the verbal or written instructions

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Exercise training

Experimental group

Description:

Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer.

Treatment:

Behavioral: Exercise training

Control group

Active Comparator group

Description:

Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital.

Treatment:

Other: Usual care