Effect of Exercise Training on Obstructive Sleep Apnea Syndrome Severity (EXESAS)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Sleep Apnea Syndromes; Sleep Apnea, Obstructives

Treatments: Other: Control; Other: Training

Study type: Interventional

Funder types: Other

Identifiers

NCT02463890

2015-A00490-49 (Other Identifier)

1508033

Details and patient eligibility

About

Sleep apnoea affects more than 20% of people over 65 years and is largely underdiagnosed. It does multiply tenfold the occurrence of vascular events, particularly stroke. While Continuous Positive Airway Pressure (CPAP) is currently the Gold standard treatment to prevent cerebrovascular and cardiovascular events, with a major clinical benefit, long term adherence to CPAP is a significant problem and search for alternative treatment is essential.

The investigators hypothesize that long-term exercise training would allow to reduce significantly sleep apnoea syndrome severity. Thus, in this study, the investigators will compare evolution of Apnoea Hypopnea Index (AHI) in an exercise trained group performed through in a national based non-profit organization (Fédération Française d'éducation Physique et de Gymnastique Volontaire (FFEPGV)) using a medical established program (NeuroGyV) during nine months against a control group receiving only standard dietetic and physical activity counseling.

Enrollment: 96 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients affiliated or entitled to a social security system
• Patients with AHI from 15 to 30 per hour
• Signature of consent

Exclusion criteria

• Patients being already treated for sleep apnea or clinical status (cardiovascular comorbidities) justifying an immediate initiation of CPAP
• Daytime sleepiness (ESS score > 10)
• Known respiratory or heart disease (or discovering during stress test) contraindicated exercise training
• Patients with Parkinson's disease

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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96 participants in 2 patient groups

Training

Experimental group

Description:

In this group, patients will perform 3 sessions of one hour per week of the "NeuroGyV" training program. It is a physical activity program with one session of Nordic walking, one session of "aquagym" and one session of gymnastic. Program lasts 9 months.

Treatment:

Other: Training

Control

Other group

Description:

In this group, patients will receive only diets and physical activity counselling

Treatment:

Other: Control