Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)

Hannover Medical School (MHH)

Status

Completed

Conditions

Metabolic Syndrome X

Treatments

Behavioral: physical exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT00515476

4031215

Details and patient eligibility

About

The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-Cholesterol in these patients. Additionally the investigators aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with metabolic syndrome and the changes dependent on physical activity of patients.

Enrollment

24 estimated patients

Sex

All

Ages

21 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Reduced HDL-Cholesterol levels in blood: < 40 mg/dl (1.03 mmol/L) in male, < 50 mg/dl (1.29 mmol/L) in female
Plus two of the following criteria:
Elevated waist circumference: ≥ 102 cm (≥ 40 inches) in men or ≥ 88 cm (≥ 35 inches) in women
Elevated triglycerides: ≥ 150 mg/dL (1.7 mmol/L
Elevated blood pressure: ≥ 130 mmHg systolic blood pressure or ≥ 80 mmHg
diastolic blood pressure or anti-hypertensive treatment
Elevated fasting glucose: ≥ 100 mg/dL or on drug treatment for elevated fasting glucose

Exclusion criteria