Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation

Johann Wolfgang Goethe University Hospital

Status: Completed

Conditions: Platelet Function; Blood Coagulation

Treatments: Other: in vitro study

Study type: Interventional

Funder types: Other

Identifiers

NCT02594345

ExoRBC

Details and patient eligibility

About

This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.

Full description

The blood of 25 healthy volunteers will be exposed to exosomes derived from red blood cell units. The effects on coagulation and platelet function will be measured using thromboelastometry (ROTEM®) and FACS analysis.

Enrollment: 18 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers

Exclusion criteria

• pregnancy
• drug use

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Intervention group

Experimental group

Treatment:

Other: in vitro study