Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

QinetiQ

Status: Completed

Conditions: Bone Resorption; Feeding Patterns

Treatments: Other: Overnight fast

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01505348

QQ-SP751

Details and patient eligibility

About

This study examined changes in bone metabolism (markers of bone turnover, calcium metabolism) with a bout of acute treadmill running preceded by either a single, mixed meal or an overnight fast.

Full description

Ten physically active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% VO2max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before exercise, during exercise, for 3h after exercise and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for β CTX, P1NP, OC, bone ALP, PTH, ACa, PO4, OPG, cortisol, leptin and ghrelin.

Enrollment: 10 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• history of weight bearing exercise
• fasting vitamin D concentration of >30 nmol•L-1 and/or a fasting parathyroid hormone (PTH) concentration of <6.9 pmol•L-1.

Exclusion criteria

• smokers
• suffered a bone fracture in the previous 12 months
• musculoskeletal injury
• condition/medication known to affect bone metabolism

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

Fasting

Experimental group

Description:

Overnight fast

Treatment:

Other: Overnight fast

Feeding

No Intervention group

Description:

Normal breakfast