Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning in Impaired Glucose Tolerant (IGT) Men

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Glucose Intolerance

Treatments: Dietary Supplement: High feeding frequency (14x); Dietary Supplement: low feeding frequency (3x)

Study type: Interventional

Funder types: Other

Identifiers

NCT01456754

MEC 10-3-057

Details and patient eligibility

About

The purpose of this study is to determine the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning in impaired glucose tolerant (IGT) men.

Enrollment: 11 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI: 20-35 kg/m2
• Gender: Male
• Age: subjects has to be older than 18 and younger than 70 years old
• Impaired Glucose Tolerant (IGT) = plasma glucose, two hours after consuming 75g glucose, appears to be superior to 7.8mmol/l (normal level) but remains inferior to 11.1mmol/l (diabetes level) and fasting plasma glucose is less than 7.0mmol/l.
• Caucasian

Exclusion criteria

1. Lactose intolerant
2. Diabetes Mellitus
3. Cardiovascular diseases
4. Stomach and intestinal diseases
5. Normal glucose levels after 2 hours
6. Anticoagulants
7. Medication that has a effect on energy and glucose homeostasis and absorption of foods
8. Conditions or situations when subjects can't lose 500 ml blood

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

11 participants in 2 patient groups

High feeding frequency (14x)

Experimental group

Treatment:

Dietary Supplement: High feeding frequency (14x)

low feeding frequency (3x)

Experimental group

Treatment:

Dietary Supplement: low feeding frequency (3x)