Effect of Flax, Poppy, Sesame & Salba on Postprandial Blood Glucose Response, Vascular, Appetite & Sensory Parameters

Unity Health Toronto

Status and phase: Completed; Phase 1

Conditions: Cardiovascular Diseases

Treatments: Dietary Supplement: Poppy; Dietary Supplement: Sesame; Dietary Supplement: Flaxseed; Dietary Supplement: Wheat Bran; Dietary Supplement: Salba

Study type: Interventional

Funder types: Other

Identifiers

NCT01579656

GLUSEED-2

Details and patient eligibility

About

Consumption of whole grains has been heavily endorsed by both government and major health agencies, as evidenced in Health Canada's Food Guide, the US Department of Agriculture's Food Pyramid, and the Heart and Stroke Foundation's healthy eating guide. Whole grains have been championed for their proposed cardioprotective and weight control effects as suggested by epidemiological studies. The health benefits of whole grain products may be attributable to their nutrient composition, which contains dietary fibre, protein and several essential nutrients. There has also been a concurrent increase in seed consumption. Seeds have a similar and potentially superior nutritional composition to whole grains and they are rich in mammalian lignans and polyunsaturated fats, especially the highly valued omega-3 fatty acids. Preliminary studies on seeds have shown that they impart health benefits similar to those imparted by whole grains. Consumer choices regarding seed consumption may be based on their potential health benefits. Furthermore, they may also be affected by subjective sensory factors, such as appearance, taste and pre-conceived perceptions. Therefore, this study will compare the health properties of four seeds and their effects on appetite and sensory parameters in healthy individuals. These four seeds will be that of flax, poppy and sesame, due to their popularity and consumption as well as Salba, which has also recently received much attention for its associated health benefits.

Enrollment: 21 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-65 years
• normal glycemic response
• BMI between 18.5 - 25 kg/m2
• peripheral systolic and diastolic blood pressure < 140mmHg and < 90mmHg

Exclusion criteria

• known history of liver or kidney disease, diabetes, hypertension, stroke or myocardial infarctions, thyroid disease, Celiac disease/gastrointestinal disease, or AIDS;
• allergies to any of the test products
• using prescription medications or Natural Health Products
• any condition which, in the opinion of the investigator, might jeopardize the health and safety of the subject or study personnel, or adversely affect the study results

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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21 participants in 5 patient groups, including a placebo group

Salba

Experimental group

Description:

25g of ground Salba baked into a bran muffin

Treatment:

Dietary Supplement: Salba

Poppy

Experimental group

Description:

25g of ground poppy seeds baked into a bran muffin

Treatment:

Dietary Supplement: Poppy

Flaxseed

Experimental group

Description:

25g of ground flaxseed baked into a bran muffin

Treatment:

Dietary Supplement: Flaxseed

Sesame

Experimental group

Description:

25g of ground sesame seeds baked into a bran muffin

Treatment:

Dietary Supplement: Sesame

Wheat Bran

Placebo Comparator group

Description:

Bran muffin matched for total available carbohydrates, total dietary fibre and calories

Treatment:

Dietary Supplement: Wheat Bran