Effect of Folic Acid Treatment in Coronary Artery Disease

University of Oxford

Status and phase: Unknown; Phase 2

Conditions: Coronary Artery Disease

Treatments: Drug: Folic Acid

Study type: Interventional

Funder types: Other

Identifiers

NCT00300352

04.OXB.004

Details and patient eligibility

About

We seek to examine the effects of folic acid treatment on vascular function in patients with coronary artery disease. Our hypothesis is that folic acid treatment will improve vascular function

Full description

Common vascular disease states including diabetes and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Folates are thought to improve endothelial function,but the mechanism by which this effect occurs is poorly understood. We propose to study the effects of folate supplementation on endothelial function in patients with coronary artery disease.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Clinical diagnosis of coronary artery disease

Exclusion criteria

Recent acute coronary event Renal and/or hepatic dysfunction Metallic implants

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind