Effect of Food Insulin Index on Metabolic Parameters in Obese Adolescents

TC Erciyes University

Status

Completed

Conditions

Pediatric Obesity

Treatments

Other: LGI-HII Breakfast

Other: LGI-LII Breakfast

Study type

Interventional

Funder types

Other

Identifiers

NCT03387293

116S069

Details and patient eligibility

About

The aim of this study was to determine the effect of food insulin index (FII) on metabolic parameters and appetite in obese adolescents with insulin resistance. A randomized, single-blind and crossover trial included 15 obese adolescents aged 12-18 years with insulin resistance. All participants were submitted two different breakfasts: low glycemic index, low insulin index (LGI-LII) and low glycemic index, high insulin index (LGI-HII), with a 1-week washout period between meals. At time 0 (just before breakfast), 15, 30, 45, 60, 90, 120, 180 and 240 minutes after the meal, serum glucose, insulin and c-peptide levels were measured and appetite was evaluated by visual analog scale. At the end of four hours, participants were served ad libitum lunch meal. Then, the foods eaten at lunch were recorded and their energy and nutrient analysis was calculated.

Enrollment

22 patients

Sex

All

Ages

12 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged 12-18 years
Age- and sex-specific body mass index (BMI) ≥95th percentile of the World Health Organization (WHO) growth-reference data
New diagnosis and not receiving any treatment
Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) >3.16

Exclusion criteria

Hypertension, cardiovascular disease, diabetes mellitus or any other significant metabolic, endocrine or gastrointestinal disease
Use of tobacco or alcohol
Taking any medications
Having difficulties for physical activity