Effect of Frankincense Extract Gel on Non-Surgical Treatment of Chronic Periodontitis

Tanta University

Status and phase: Unknown; Phase 2

Conditions: Chronic Periodontitis

Treatments: Procedure: scaling and root planing; Procedure: Frankincense extract gel natural herbal product

Study type: Interventional

Funder types: Other

Identifiers

NCT05005767

2D

Details and patient eligibility

About

This study will evaluate the effect of the subgingival application of Frankincense extract gel as an adjunct to scaling and root planning (SRP) in chronic periodontitis.

Full description

: twenty patients will be randomly selected and equally divided into Group I: will receive SRP only, group II: will receive SRP and Frankincense extract the gel. Subgingival application of Frankincense extract gel will be performed following initial SRP )day 1) and at 7, and 14 days. Clinical measurements included pocket depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). Real-time PCR was carried out to determine the effect of the treatment on Porphyromonas gingivalis (Pg). Clinical measurements and Plaque samples for PCR were recorded at baseline (before treatment), one, and three months after treatment.

Enrollment: 20 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• systemically healthy patients were selected
• patients who had not received any medications for the previous six months that may interfere with periodontal tissue health or healing.
• Patients should demonstrate their ability to maintain good oral hygiene

Exclusion criteria

• Smokers and pregnant patients.
• Medically compromised patients and systemic conditions precluding periodontal surgery.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups, including a placebo group

Placebo group

Placebo Comparator group

Description:

ten patients with sites suffering from mild chronic periodontitis sites will be treated with scaling and root planing (SRP) only

Treatment:

Procedure: scaling and root planing

test group

Active Comparator group

Description:

Ten patients with sites suffering from mild chronic periodontitis. sites will be treated with scaling and root planing (SRP) and subgingival application of Frankincense extract gel

Treatment:

Procedure: Frankincense extract gel natural herbal product

Procedure: scaling and root planing