Effect of Fresh Gas Flow Differences on Postoperative Nausea and Vomiting

Adiyaman University Research Hospital

Status: Completed

Conditions: Septoplasty/Septorhinoplasty; Nausea and Vomiting, Postoperative

Treatments: Other: 4 lt/dk fresh gas flow; Other: 0.5 lt/dk fresh gas flow; Other: 2 lt/dk fresh gas flow

Study type: Interventional

Funder types: Other

Identifiers

NCT06952946

AURH-AR-UK-01

Details and patient eligibility

About

The aim of this study is to investigate the effect of fresh gas flow applied during general anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing septorhinoplasty surgery. Patients who agree to participate in the study will be divided into three groups according to the fresh gas flow applied: low flow (0.5 lt/min) (Group L), medium flow (2 lt/min) (Group M) and high flow (4 lt/min) (Group H), and the postoperative nausea and vomiting data of the groups will be compared.

Full description

Preoperative demographic characteristics and Apfel score (smoking history, gender, postoperative opioid use, POB history) of the patients will be recorded. General anesthesia will be applied to all patients with standard ASA monitoring. In general anesthesia induction, 2 mg/kg propofol, 1 mcg/kg remifentanil, 0.6 mg/kg rocuronium will be used for all patients. Sevoflurane (minimum alveolar concentration of 1) will be used as a volatile agent and remifentanil (0.1 mcg-1 mcg/kg/h) will be used as an analgesic agent for anesthesia maintenance. After endotracheal intubation, fresh gas flow will be applied at 4 lt/min for 8 minutes, reduced to 0.5 lt/min in Group L, 2 lt/min in Group M, and maintained at 4 lt/min in Group H. After extubation, patients will be monitored in the recovery unit for at least 30 minutes, and at postoperative 0th minute (when first seen in the recovery room), 30th minute, 1st hour, 6th hour, 12th hour and 24th hour, the nausea score of the patients will be evaluated using the Numerical Rating Scale (NRS) with a score between 0 and 10. If vomiting is present, the number of times the patient vomited will be questioned and recorded. The patients' postoperative VAS scores, the amount of antiemetics used, the amount of opioids used intraoperatively and postoperatively will be recorded, and comparisons will be made between the groups and evaluated.

Enrollment: 150 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who agreed to participate in the study
• 18-65 years of age
• ASA I-II risk group patients

Exclusion criteria

• Patient does not accept the study
• Presence of psychiatric disorder and patient's inability to cooperate
• Cognitive dysfunction
• Hearing problems
• History of alcohol or drug addiction
• Presence of a serious pre-existing medical condition that limits objective assessment
• Complications developed during surgery
• Presence of any life-threatening condition after surgery
• Patient's classification is ASA III-IV

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 3 patient groups

low flow anesthesia group

Active Comparator group

Description:

After endotracheal intubation, fresh gas flow will be applied at 4 lt/min for 8 minutes, and in the low-flow anesthesia group, it will be reduced to 0.5 lt/min and maintained at this flow throughout the surgery.

Treatment:

Other: 0.5 lt/dk fresh gas flow

medium flow anesthesia group

Active Comparator group

Description:

After endotracheal intubation, fresh gas flow will be applied at 4 lt/min for 8 minutes, and in the medium-flow anesthesia group, it will be reduced to 2 lt/min and maintained at this flow throughout the surgery.

Treatment:

Other: 2 lt/dk fresh gas flow

high flow anesthesia group

Active Comparator group

Description:

After endotracheal intubation, fresh gas flow will be applied at 4 lt/min for 8 minutes and then continued in the same manner (4 lt/min) in the high-flow anesthesia group.

Treatment:

Other: 4 lt/dk fresh gas flow