Effect of Fully Blocking Type 1 Angiotensin Receptor on Target Organ Damage of Postmenopausal Hypertensive Women

Lanzhou University

Status: Unknown

Conditions: Hypertension

Treatments: Drug: Valsartan 1; Drug: Valsartan 80 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT03432468

LanZhouU

Details and patient eligibility

About

This study compared the improvements of blood pressure levels, left ventricular hypertrophy, left ventricular diastolic function, vascular function and cognitive function between postmenopausal hypertensive women and age-matched hypertensive male patients through the evaluation of the effects of fully blocked AT1 receptor by valsartan. Additionally, the differences of the above indexes between the patients who were fully blocked AT1 receptor by valsartan and the patients who were treated with a single dose of valsartan treatment were assessed, so as to provide theory basis for clinical treatment of postmenopausal hypertensive women.

Enrollment: 102 estimated patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of hypertension
• Women are all postmenopausal
• Must provide written informed consent

Exclusion criteria

• Secondary hypertension
• Coronary disease
• Heart failure
• Arterial fibrillation
• Previous myocardial infarction
• Previous stroke
• Malignant disease
• Kidney failure
• Liver failure
• Neoplastic disease
• Severe neurological diseases
• Severe metabolic or organic decompensation
• Refuse to sign the informed consent form

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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102 participants in 2 patient groups, including a placebo group

postmenopausal hypertensive women

Active Comparator group

Treatment:

Drug: Valsartan 1

Drug: Valsartan 80 mg

age-matched hypertensive male patients

Placebo Comparator group

Treatment:

Drug: Valsartan 1