Effect of Furosemide on Confirmation of Ureteral Patency During Routine Cystoscopy

University of South Florida

Status and phase: Completed; Phase 4

Conditions: Cystoscopy

Treatments: Drug: furosemide; Drug: Normal Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02960412

Pro00026976

Details and patient eligibility

About

This study evaluates if administration of IV furosemide leads to expedited confirmation of ureteral patency when compared to placebo (IV saline) in routine cystoscopy performed after urogynecologic surgery.

Full description

Cystoscopy is performed routinely after urogynecologic surgery to ensure there was no injury to the urinary tract (urethra, bladder, or ureters). In order to confirm that no damage occurred to the ureters, a jet of urine must be visualized from each ureteral opening.

The time it takes to confirm this ureteral patency is variable and some sources suggest using furosemide to decrease the time it takes to see these jets. This study will evaluate what effect, if any, this medicine has on time to confirming ureteral patency.

Enrollment: 150 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Undergoing any urogynecologic surgery
• No allergy or contraindication to receiving furosemide
• Normal Creatinine/glomerular filtration rate

Exclusion criteria

• Unable to consent, including if non English speaking
• Allergy or contraindication to receiving furosemide
• Intraoperative injury to the lower urinary tract

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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150 participants in 2 patient groups, including a placebo group

furosemide

Experimental group

Description:

furosemide 10mg (1mL) IV push for one dose

Treatment:

Drug: furosemide

placebo

Placebo Comparator group

Description:

normal saline 1mL IV push for one dose

Treatment:

Drug: Normal Saline