Effect of Gabapentin on Idiopathic Subjective Tinnitus

Islamic Azad University of Mashhad

Status and phase: Unknown; Phase 2

Conditions: Subjective Tinnitus

Treatments: Drug: placebo; Drug: Gabapentin

Study type: Interventional

Funder types: Other

Identifiers

NCT00555776

Gaba-tinntus-145

Details and patient eligibility

About

The purpose of this study is to determine wether Gabapentin which is useful for treating neuropathic pains, is effective on idiopathic subjective tinnitus.

Full description

Tinnitus is the perception of sound in the absence of acoustic stimulation. It can be subjective or objective. .

Despite numerous researches,no effective treatment for people who suffer from tinnitus has yet been stablished.

As there are many evidences suggesting that loss of inhibition in the central nervous system may be responsible for many aspects of auditory dysfunction,including tinnitus; and as Gabapentin (Neurontin), a gama-aminobutyric acid (GABA) analogue, is an effective medication in conditions where inhibition in the CNS is impaired; we guess that Gabapentin might be useful for treating idiopathic subjective tinnitus.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with subjective idiopathic tinnitus

Exclusion criteria

• tinnitus with known underlying cause
• pregnant women and patients younger than 18 or older than 75 years
• patients with impaired renal function

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups, including a placebo group

1

Active Comparator group

Description:

Randomly,half of the subjects are given Gabapentin.

Treatment:

Drug: Gabapentin

2

Placebo Comparator group

Description:

Randomly,half of the subjects receive placebo.

Treatment:

Drug: placebo