Effect of Gabapentin on Pain of the Second Cataract Surgery

Seoul National University

Status and phase: Unknown; Phase 4

Conditions: Hyperalgesia

Treatments: Drug: placebo; Drug: gabapentin

Study type: Interventional

Funder types: Other

Identifiers

NCT02127853

SerialCataractGaba

Details and patient eligibility

About

Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.

Full description

Hyperalgesia occurring at the second operation in bilateral eye surgery is well known, and mechanism of central sensitization might be involved. Gabapentin is known to lower the effect of central sensitization, and its effect on acute postoperative pain has been reported. Therefore, pretreatment of gabapentin after first operation may reduce the pain at second operation.

Enrollment: 70 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient of ASA(American Cociety of Anesthesiology) class I, II, III between age 20 to 80, scheduled for serial bilateral cataract surgery(1 weel interval)

Exclusion criteria

• refuse to participate
• BMI<16 or BMI >30
• severe cardiovascular, pulmonary, renal disease
• alcohol or drug abuse
• currently taking CNS(central nervous system) inhibitory drugs
• taking antiacids
• depressive disorder pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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70 participants in 2 patient groups, including a placebo group

Gabapentin

Experimental group

Description:

gabapentin pretreatment

Treatment:

Drug: gabapentin

Placebo

Placebo Comparator group

Description:

placebo drug pretreatment

Treatment:

Drug: placebo