Effect of Gastric Bypass Surgery on Brain Responses

Uppsala University

Status: Suspended

Conditions: Obesity; Hormone Responses; Cognitive Health

Treatments: Procedure: Bariatric surgery; Behavioral: Memory performance; Behavioral: Brain activity in resting state

Study type: Interventional

Funder types: Other

Identifiers

NCT01815216

PH2013b

EPN 2012/451 (Other Identifier)

Details and patient eligibility

About

After obesity surgery gastric bypass (GBP) patients usually lose more than 50% of its former preponderance in relative short time (~ 2 years). But knowledge of the underlying biological mechanisms of decline in body weight is still inadequate.

This project intends to examine patients' background activity in the brain (i.e. "the resting state activity") and brain volume using MRI both before and one year after surgery.

Full description

We will also investigate whether hormonal changes in response to food intake after obesity surgery is associated with patients' impulsive control when exposed to pictures of food in the MRI.

Enrollment: 48 estimated patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female
• right-handed
• scheduled for bariatric surgery in the Academic Hospital of Uppsala, Sweden

Exclusion criteria

• undergone more than one bariatric surgery
• suffer from mental disorders (depression, phobias, etc.) that can not be controlled with treatment.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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48 participants in 2 patient groups

Bariatric surgery

Experimental group

Description:

patients participating in the intervention group , i.e. assessing effects of bariatric surgery on: Brain activity in resting state Memory performance

Treatment:

Behavioral: Brain activity in resting state

Behavioral: Memory performance

Procedure: Bariatric surgery

Control

Active Comparator group

Description:

Patients in the control group will not undergo surgery during study. These patients will be examined twice: 1. 9 weeks before the operation (i.e. clinical intervention to reduce body weight has not started). 2. after 4 weeks of low-calorie diet (which will be a week before their surgery, when patients are in a catabolic metabolism because they eat much less energy than is needed) to assess effect of acute weight loss on: Brain activity in resting state Memory performance

Treatment:

Behavioral: Brain activity in resting state

Behavioral: Memory performance