Effect of Gastric Bypass Surgery on Pancreatic Islet and Incretin Function - Follow-up Study

Hvidovre University Hospital

Status: Completed

Conditions: Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT02161666

AB-CD-10-2Y

Details and patient eligibility

About

To examine pancreatic islet function and incretin function during intravenous and oral stimulation >2 years after gastric bypass surgery in patients with normal glucose tolerance. We hypothesize that islet cell and incretin function is enhanced in response to oral, but not intravenous, stimulation - i.e. incretin released from the gut in response to oral stimulation play a key role for the enhanced islet function after gastric bypass surgery.

Enrollment: 7 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participation in previous study (NCT01559779)

Exclusion criteria

• Pregnancy/lactation
• Major chronic disease develop since previous examination with possible impact on outcomes

Trial design

7 participants in 2 patient groups

Patients

Description:

Morbidly obese patients with normal glucose tolerance undergoing gastric bypass surgery

Controls

Description:

Age, sex and BMI-matched healthy controls