Effect of General Anesthesia Method on Cardiac Risk Patients on Ischemia Modified Markers

Ataturk University

Status: Not yet enrolling

Conditions: Anesthesia

Treatments: Procedure: TIVA; Procedure: GENERAL ANESTHESIA

Study type: Interventional

Funder types: Other

Identifiers

NCT05662163

B.30.2.ATA.0.01.00/296

Details and patient eligibility

About

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers

Full description

To examine the effects of the general anesthesia method chosen in non-cardiac surgical operations of patients with cardiac risk on the levels of cardiac markers like; serum levels of the Creatine Kinase, Creatine Kinase Myocardial Band, high sensitive troponin, heart-type fatty acid-binding protein, ischemia-modified albumin and albumin. And evaluate the effect of anesthesia method on haemodynamic.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being 18 years or older
• Getting a score of 2 and above according to the Lee cardiac index
• Having a non-cardiac surgical procedure that will take at least three hours
• ASA II or III

Exclusion criteria

• Under 18 years old
• Those who refused to participate in the study
• Patients with chronic renal failure
• Patients with creatinine value ≥ 1.5 mg/dl
• Surgery that takes less than 3 hours
• Patients with liver failure
• Refusing to participate in the study
• Being allergic to the drugs used

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

GROUP TIVA

Active Comparator group

Description:

Anesthesia will be maintained with propofol (6-10 mg/kg/hour) and remifentanil (0.1-0.3 μg/kg/min). Blood will be taken from the patients at 0, 1 and 4 hours, centrifuged and stored at -80 degrees. From these examples, CK, CKMB, HIGH SENSITIVE TROPONIN, HFABP, IMA AND ALBUMIN will be studied.

Treatment:

Procedure: TIVA

GROUP INHALATION ANESTHESIA

Active Comparator group

Description:

Anesthesia will be maintained with sevoflurane (2 ml/min) 50% oxygen and remifentanil (0.1-0.3 μg/kg/min). Blood will be taken from the patients at 0, 1 and 4 hours, centrifuged and stored at -80 degrees. From these examples, CK, CKMB, HIGH SENSITIVE TROPONIN, HFABP, IMA AND ALBUMIN will be studied.

Treatment:

Procedure: GENERAL ANESTHESIA