Effect of General Anesthesia on Enterocyte Damage (GUT)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: General Anesthesia; Non-urgent Surgery

Study type: Observational

Funder types: Other

Identifiers

NCT02199275

P/2013/174

Details and patient eligibility

About

During non urgent surgery, general anesthesia might induce enterocyte damage. I-FABP is a performant biomarker of enterocyte damage. We aimed to study whether patient ongoing general anesthesia for non-urgent surgery have an elevation of plasma I-FABP concentration.

Full description

Inclusion criteria

• Indication of non-urgent surgery
• General anesthesia protocol using propofol and remifentanyl
• One half of the patients have a history of ischemic arteriopathy
• One half of the patients have no history of ischemic arteriopathy

Exclusion criteria

• Age < 18 years old
• Pregnant

Primary objective

Is there a significant elevation of I-FABP between the pre-anesthesic period and 11 minutes after induction of general anesthesia ?

Secondary objectives

1. Is I-FABP elevation higher among patients with history of patent arteriopathy ?
2. Is I-FABP elevation higher among patients presenting with hypotension during anesthesia ?

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

• Indication of non-urgent surgery
• General anesthesia protocol using propofol and remifentanyl
• One half of the patients have a history of ischemic arteriopathy
• One half of the patients have no history of ischemic arteriopathy

Exclusion criteria

• Age < 18 years old
• Pregnant