Effect of Glucosamine on Intraocular Pressure

Shahid Beheshti University of Medical Sciences

Status and phase: Unknown; Phase 3

Conditions: Intraocular Pressure Changes After Glucosamine Sulfate Consumption.

Treatments: Drug: glucosamine sulfate 1500 mg three times a day; Drug: Placebo three times a day

Study type: Interventional

Funder types: Other

Identifiers

NCT02306083

92182

Details and patient eligibility

About

In this double blind clinical trial 92 patients suffering from rheumatoid arthritis are included. Those with the history of intraocular and corneal surgery, diabetic and heavy smokers are excluded from the study. Before starting the treatment all patients undergo complete ophthalmic exam, corneal biomechanical properties assessment by Ocular Response Analyzer (ORA) and corneal thickness measurement. Patients are randomly assigned to treatment and placebo groups. Those in the treatment groups receive glucosamine sulfate 1500 mg three times a day. Those in placebo arm receive alike capsule with the same schedule. At month 3 and 6 IOP(intraocular pressure), ORA and pachymetry would be checked again.

Enrollment: 41 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• History of rheumatoid arthritis based on ACR (American College of Rheumatology)FC(functional classes).
• No history of using drugs tested in the study.

Exclusion criteria

• History of any kind of corneal surgery.
• History of intraocular surgery.
• History of diabetes mellitus.
• Heavy smokers.
• Unwillingness to participate in the study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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41 participants in 2 patient groups, including a placebo group

Administration of the Placebo

Placebo Comparator group

Description:

Placebo three times a day.

Treatment:

Drug: Placebo three times a day

Administration of the glucosamine sulfate

Placebo Comparator group

Description:

glucosamine sulfate 1500 mg three times a day

Treatment:

Drug: glucosamine sulfate 1500 mg three times a day