Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

Bispebjerg Hospital

Status and phase: Unknown; Phase 1

Conditions: Osteoarthritis of the Knee

Treatments: Drug: ibuprofen; Drug: placebo; Drug: glucosamine sulphate

Study type: Interventional

Funder types: Other

Identifiers

NCT00833157

HIM-037

KF-01-18904

Details and patient eligibility

About

The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.

The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.

Enrollment: 36 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 50 to 70 years
• Bilateral tibiofemoral osteoarthritis of the knee on x-ray
• American College of Rheumatology (ACR) clinical classification criteria

Exclusion criteria

• Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases
• Excess alcohol use (> 21 alcoholic drinks per week)
• Severe overweight (BMI > 35)
• History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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36 participants in 3 patient groups, including a placebo group

Glucosamine

Experimental group

Treatment:

Drug: glucosamine sulphate

Ibuprofen

Experimental group

Treatment:

Drug: ibuprofen

Placebo

Placebo Comparator group

Treatment:

Drug: placebo