Effect of Glucose 5% on Labor Length

Suez Canal University

Status: Unknown

Conditions: Induction of Labor Affected Fetus / Newborn

Treatments: Drug: Dextrose 5%/Nacl 0.3% Inj_#3; Drug: Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT04492150

4018

Details and patient eligibility

About

Induction of labor, is one of the most common obstetric procedures done routinely in modern obstetrics. For example, in USA, 23% of pregnant women in 2012 (about 1 million) underwent an induction of labor. However, accurate data about percentage of women undergoing induction of labor in Egypt is not accurately known.

One of the recent research era in current obstetrics is the optimal intravenous (IV) hydration of the pregnant women in labor.Current evidences available in our hands, suggest that maternal hydration appears to fasten labor progress and enhance the action of oxytocin, if the later is used for augmentation. However, the addition of glucose supplementation to this IV hydration to enhance uterine contraction, as a matter of safety and efficacy, is controversial

Enrollment: 476 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (>18 years) multiparous women
• Late Term Pregnancy ( gestational Age Between 40-42 weeks)
• Uncomplicated singleton pregnancy with cephalic presentation.
• Favorable cervix for induction (Bishop score<6) without ruptured membranes.

Exclusion criteria

• Women with chronic diseases or complicated pregnancy; gestational and pre gestational ( type 1 & 2)diabetes, preeclampsia and\or renal and\or maternal heart diseases.
• Non-cephalic presentations, multiple pregnancies, or cervix unfavorable for induction.
• Other indications for cesarean delivery

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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476 participants in 2 patient groups

study group

Experimental group

Description:

women who will receive 250 mL/hour of dextrose 5% with normal saline in a 1:1 ratio.

Treatment:

Drug: Saline

Drug: Dextrose 5%/Nacl 0.3% Inj_#3

control group

Active Comparator group

Description:

women who will receive 250 mL/hour of normal saline for the whole duration of induction

Treatment:

Drug: Saline