Effect of Glucose Control on the Response to Aspirin in Type 2 Diabetic Patients

Hadassah Medical Center

Status: Completed

Conditions: Diabetes Mellitus, Type II

Study type: Observational

Funder types: Other

Identifiers

NCT00649909

0020-08-HMO-CTIL

Details and patient eligibility

About

The efficacy of low dose aspirin appears to be substantially lower in diabetic patients, compared to patients without diabetes.

We will perform an observational study where we follow up patients with uncontrolled type 2 Diabetes Mellitus and low response to aspirin (Aspirin Resistance), during a period of 6 months in the diabetic clinic. Our hypothesis is that glucose control will improve the response to aspirin in those patients.

Enrollment: 18 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

1. Type 2 DM.
2. Patients that take aspirin.
3. Antecubital forearm veins allowing technically good sampling for platelet studies.
4. Reduced Laboratory response to aspirin.
5. HbA1c > 8 %
6. The physician decides that there is an indication for glucose control.

Exclusion Criteria:

1. Acute ischemic stroke, acute coronary syndrome, (myocardial infarction or unstable angina pectoris), or revascularization by PCI or by-pass surgery within the last 6 months.
2. Acute kidney disease or chronic kidney disease with creatinine clearance <30.
3. Acute liver disease or chronic liver disease with severe liver impairment.
4. Need for treatment with anticoagulants, clopidogrel, NSAID's, or thiazolidinediones.
5. Thrombocytopenia (platelet count <150 x 109/L)

Trial design

18 participants in 1 patient group

Observation

Description:

Type 2 diabetic patients with reduced laboratory response to aspirin.(Aspirin Resistance)and with HbA1c \>8%.