Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Acute Coronary Syndrome

Treatments: Drug: GIK solution

Study type: Interventional

Funder types: Other

Identifiers

NCT01384656

4-2009-0689

Details and patient eligibility

About

Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion on myocardium in patients undergoing OPCAB. Patients undergoing OPCAB with acute coronary syndrome are randomly assigned to GIK or Control group. The trial is double-blind and conducted at a single center.

Enrollment: 66 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing isolated OPCAB.
• Age: 20~75.

Exclusion criteria

• Emergency operation.
• Patients with MR ≥ 2.
• Patients with IDDM.
• Patients with random sugar ≥ 250 mg/dL.
• Patients with serum creatinine ≥ 2.0 mg/dL.
• Patients with acute myocardial infarction within 1 week of surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

66 participants in 2 patient groups, including a placebo group

GIK group

Experimental group

Treatment:

Drug: GIK solution

Control group

Placebo Comparator group

Treatment:

Drug: GIK solution