Effect of Glutamine on Gastric Emptying and Length of Parenteral Nutrition in Premature Neonates

University Hospital, Rouen

Status and phase

Completed

Phase 4

Conditions

Enteral Feeding

Treatments

Dietary Supplement: glutamine (dipeptiven)

Study type

Interventional

Funder types

Other

Identifiers

NCT00213668

2000/111/HP

Details and patient eligibility

About

This study investigates the effects of enterally supplied glutamine on gastric emptying, intestinal transit, age of total enteral nutrition and age at the end of hospitalisation. Forty neonates, aged at least 2 days and free of acute illness participate in a prospective, randomised, double-blind study. All are fed with parenteral and enteral nutrition enriched with glutamine (0.7 g/kg/per day, group 1) or isonitrogenous control (group 2). Gastric emptying is analysed by sequential measure of intragastric residue by diluted polyethylene glycol (PEG) 4000. Intestinal transit is analysed by Rouge Carmin test.

Sex

All

Ages

2 to 10 days old

Volunteers

No Healthy Volunteers

Inclusion criteria

Premature neonates aged 30-33 weeks of gestational age
Aged at least 2 days and no more than 10 days
Free of acute illness
Written informed consent is obtained from the parent prior to enrolment.

Exclusion criteria

Premature infants with respiratory (fraction of inspired oxygen [FiO2] > 30%), or cardiovascular, liver, intestinal or acute diseases
Premature infants with congenital syndrome